CDP Choline

CDP Choline

CDP Choline (cytidine 5’-diphosphocholine) is a nootropic supplement often used by individuals seeking to support general brain health and cognition. It is regarded as a cholinergic supplement in that it increases the bioavailability of choline for utilization by the brain and body. This increase is most notable for being utilized by the central nervous system and various brain cells. The additional molecule in CDP Choline, Cytidine, contributes to its function as a nootropic. Cytidine may act to protect neurons as its metabolite, uridine, is used to create cell membranes.
As a nootropic supplement, CDP Choline is mostly known for its ability to influence various cognitive processes and neuronal functions. Most users and studies report benefits in the following areas:

  • Cognitive Support: May help with general cognitive functions.
  • Mental Performance: May improve mental performance.
  • Mood: May support general feelings of well-being.
  • Brain Health: May help improve overall brain health.
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The method of action for CDP Choline’s effects are mostly derived from its ability to influence the health and function of neurons. It does this in several ways, including maintaining the health of neurons, increasing the utilization of certain neurotransmitters, helping to restore the structural integrity of neurons, and more. These actions may make CDP Choline a favorable nootropic supplement.
One possible cause for CDP Choline aiding in general cognitive functions is its influence on levels of choline available for utilization by the brain and its neurotransmitters. Primarily, this influx of choline is used in order to synthesize acetylcholine, a key neurotransmitter for neuronal communication. Studies have shown CDP Choline to have a beneficial effect on memory performance and learning due to these pharmacological activities. It has also been shown to influence the rate at which the brain utilizes available nutrients (cerebral metabolism), while also increasing the release of noradrenaline and dopamine. This may benefit mental performance during challenging tasks as increased levels of noradrenaline and dopamine are often associated with increases in focus and attention. Dopamine is also a neurotransmitter responsible for feelings of well-being, which may explain CDP Choline’s effect on mood.
Studies have also shown CDP Choline to have beneficial effects on brain health. One possible cause is its ability to assist in the formation of cell membranes. It does this by converting into an intermediate during the synthesis of acetylcholine. This intermediate, phosphatidylcholine, is utilized in the creation of cell membranes. Cytidine also assists in the generation of cell membranes once converted to uridine. Uridine also acts as a neuroprotective molecule as it influences levels of NGF (neuron growth factor). NGF is a protein responsible for generating and maintaining the integrity of neurons and synapses. Studies have shown elevated levels of NGF to be beneficial for learning and memory.




Studies have shown CDP Choline to have no acute toxicity and to be well tolerated by most individuals. It also has no serious effects on the cholinergic system. There are also no reported side effects within the recommended dose range.


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